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myupgrades.com/handbags/mkoutlet.php Three studies based on class I evidence have been published that have demonstrated clinical and radiographic benefits (at least in the short term) in individuals with MS who were treated at the time of the first exacerbation of their disease compared with those who were randomly allocated to receive placebo.14, 15, 16 Furthermore, extensions of these studies suggested that the individuals in whom treatment was delayed for 2 years because of allocation to placebo accrued more disease activity and, when later treated, seemed to derive much less benefit, than did those who were treated at presentation.17.
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